With United 1-0 down in their Premier League clash at Old Trafford, Rashford was presented with a perfect opportunity to level the scores.
But the England striker squandered the big chance as he struck the inside of the post after Scott McTominay was brought down in the box.
It comes after Paul Pogba missed against Wolves at Molineux in controversial fashion.
Paul Pogba v WolvesGetty Images
But now it is Rashford who has blundered from the penalty spot with United trailing.